Eco-Friendly Synthesis of water-soluble Imidazole Derivatives: Exploring Multiple Pathways and Their Catalytic Properties
DOI:
https://doi.org/10.48047/t07p8762Keywords:
Imidazole, Grinding method, Muffle Furnace, Microwave, Solid phase, Different solvent, Optimization.Abstract
In this study, we report the synthesis of water-soluble imidazole derivatives featuring base-sensitive
fluorophore peripheral units. The synthesis was carried out using various organic compounds through
conventional methods, as well as silica-supported Muffle furnace and microwave techniques. Our findings
indicate that the solvent-free synthetic approach offers significant advantages over conventional methods.
These advantages include non-toxic reagents, markedly reduced reaction times, straightforward workup
procedures without the need for extensive purification, and higher yields. Moreover, the synthesized substituted
imidazole derivatives demonstrated excellent catalytic activity in the preparation of Gembisamide derivatives
when employing the conventional synthetic approach. This highlights the potential of these derivatives in
various catalytic applications.
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