DEVELOPMENT OF FLUTAMIDE LOADED POLYMERIC NANOCARRIERS FOR CHEMOTHERAPY OF PROSTATE CANCER.
DOI:
https://doi.org/10.48047/9a6gy935Keywords:
Flutamide, Nanoparticles, Prostate Cancer and Nanoprecipitation.Abstract
Flutamide is a potent nonsteroidal anti-androgen used to treat advanced prostate cancer. It blocks
the androgen receptors on the cancer cells and inhibits the androgen dependent cell growth. This
work was planned to compile the research work available in the scientific publications in the
formulation and evaluation of Flutamide loaded polymeric nanoparticles for the treating the
prostate cancer including the study of influence of various formulation components such as
polymer concentration, organic phase volume, drug content, stabilizer concentrations and the
ratio between aqueous to organic phase in the characteristics of nanoparticles. Literature study
revealed that, methods like Ionic Gelation Technique, Solvent Evaporation method and
Nanoprecipitation have been utilized and polymers like Chitosan, casein, Methacrylic acid,
PHEA-IB-p(BMA) graft copolymer, mPEG – PLGA and PVA have been utilized. The drug
loaded polymeric nanoparticles were evaluated for their physiocochemical properties along with
characterization with FTIR, in vitro release and in vitro and in vivo anticancer potential
Downloads
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
