Coadministration of ascorbic acid and metformin ameliorates valproic acid -Induced hepatotoxicity in male rats
DOI:
https://doi.org/10.48047/54mnvt11Keywords:
metformin, ascorbic acid, valproic acid, anti-inflammatory, antioxidant, hepatotoxicityAbstract
Valproic acid is used to treat neurological disorders such as epilepsy, bipolar disorder and migraine headaches. It has been demonstrated that its usage can have bad consequences, such as hepatotoxicity. Vitamin C and metformin have anti-inflammatory and antioxidant effects. Thus, this study aimed to investigate the potential hepatoprotective effects of vitamin C and metformin pretreatment alone and in combination against hepatotoxicity of valproic acid.
Downloads
References
Rosenberg G. The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees? 2007;64:14.
Pourahmad J, Eskandari MR, Kaghazi A, Shaki F, Shahraki J, Fard JK. A new approach on valproic acid induced hepatotoxicity: Involvement of lysosomal membrane leakiness and cellular proteolysis. Toxicology in Vitro. 2012 Jun;26(4):545–51.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
