Antimicrobial Activity of Clarithromycin Nanosuspension Prepared By Precipitation Method: Formulation, Characterization and Efficacy
DOI:
https://doi.org/10.48047/dqfxjm03Keywords:
Nanosuspension technology, Clarithromycin, Antimicrobial activity, Nanoprecipitation, Particle size, Zone of inhibition.Abstract
Background: Oral drug delivery is preferred for its convenience, yet over 40% of new drugs are hydrophobic, complicating formulation. Nanosuspensions, submicron colloidal dispersions of poorly soluble drugs, offer a promising solution to enhance solubility and bioavailability. Objective: The purpose of this work was to create and assess the antibacterial activity of a clarithromycin nanosuspension against Salmonella typhi, Staphylococcus aureus, and Escherichia coli.
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References
Amidon GL, Lennernäs H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical research. 1995 Mar;12:413-20. 2. Patel VR, Agrawal YK. Nanosuspension: An approach to enhance solubility of drugs. Journal of advanced pharmaceutical technology & research. 2011 Apr 1;2(2):81-7.
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