The Role of Exosomes in Tumor Cell Communication with the Tumor Microenvironment: Clinical Chemistry Implications in Cancer Progression and Metastasis
DOI:
https://doi.org/10.48047/98vxgb49Keywords:
Exosomes • Tumor Microenvironment • Cancer Progression • Metastasis • Oncogenic Signals • Biomarkers • Immune EvasionAbstract
Exosomes, nanoscale extracellular vesicles, have emerged as pivotal players in cancer biology due to their roles in intercellular communication. These vesicles facilitate tumor progression by modulating the tumor microenvironment (TME), promoting immune evasion, angiogenesis, and metastasis. Exosomes serve as carriers of oncogenic signals, influencing stromal and immune cells
within the TME and preparing distant organs for metastasis. Clinically, they present promising applications as biomarkers for non-invasive cancer diagnostics and as vehicles for therapeutic delivery. Advances in exosome research are driving innovations in personalized medicine, addressing challenges such as therapeutic resistance and precision targeting. Future perspectives
highlight the need for further research into exosome isolation, characterization, and clinical translation to optimize their potential in cancer treatment and diagnostics.
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References
Katha, Sanyal., Abhijit, G., Banerjee. (2024). Exosomes: A Brief Review of Biology and Medical Applications. European medical journal, doi: 10.33590/emjinnov/uhte1027 2. Can, Liu., Cong, Xia., Chenglai, Xia. (2023). Biology and function of exosomes in tumor immunotherapy. 169:115853-115853. doi: 10.1016/j.biopha.2023.115853
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