An Insight about Fatigue and Sleep In Survivors of Childhood Acute Lymphoblastic Leukemia
DOI:
https://doi.org/10.48047/fz5a6b96Keywords:
Fatigue, Survivors, sleep, childhood, Acute Lymphoblastic LeukemiaAbstract
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, and most affected children
(> 90%) will become long-term survivors. Survivors and caregivers have identified fatigue as one of the most
prevalent and distressing late effects experienced following childhood cancer treatment. Fatigue can negatively
impact the lives of pediatric cancer survivors, increasing levels of depression, diminishing neurocognitive and
behavioral functioning, and impacting academic achievement and overall quality of life. Fatigue is characterized
by low energy and weariness, whereas sleepiness is the normative experience of feeling that one needs to sleep,
and is only considered a disorder when it occurs too frequently (eg, excessive daytime sleepiness) or infrequently
(eg, insomnia). Both fatigue and excessive daytime sleepiness occur in children and adolescents who have not
been affected by cancer, but rates are higher among pediatric cancer patients and survivors. Sleep disturbances
may directly result from cancer and its treatment, as well as from multiple other risk factors, many of which lead
to a bidirectional relationship between sleep and physical and psychological distress
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