The Impact of HIV Status on Anti-tuberculous Therapy: A Systematic Review and Meta-Analysis
DOI:
https://doi.org/10.48047/mq7qce15Keywords:
Anti-tuberculosis drugs, HIV, Safety, Effectiveness, Meta-analysisAbstract
Background: The global health challenge of tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection demands an in-depth
evaluation of TB treatment's safety and efficacy in individuals, regardless of their HIV status.
Objective: This study critically examines the literature to determine the effectiveness of anti-TB therapies among HIV-positive and HIV-negative
patients.
Methods: We conducted a systematic review of the literature by searching databases such as Web of Science, SCOPUS, PubMed, and the Cochrane
Central Register up to 30 August 2023. Using RAYYAN.AI for initial screening and the R programming language for meta-analysis, we extracted
and analysed outcome data, focusing on treatment success and mortality rates. The analysis included heterogeneity assessment via the I² test and bias
risk evaluation via the Newcastle-Ottawa Scale.
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