Empagliflozin-Loaded Floating Density-Modulated Drug Delivery System as a Novel Approach for Sustained Therapy in Type 2 Diabetes Mellitus with Sodium-Glucose Co-Transporter-2 Inhibition
DOI:
https://doi.org/10.48047/wsqnzm52Keywords:
Empagliflozin, Density-modulated drug delivery system (DMDDS), In Vitro Drug Release, Sustained Release, Micromeritic Properties, Type 2 DiabetesAbstract
The development of a density-modulated drug delivery system (DMDDS) for Empagliflozin aims to enhance
gastric retention and ensure sustained drug release for effective management of Type 2 Diabetes Mellitus. This
study evaluated five formulations (EMF1 to EMF5) based on micromeritic properties, weight and drug content
uniformity, in vitro floatation, and drug release kinetics. Among the formulations, EMF1 demonstrated superior
flowability, as evidenced by its lowest Carr’s Index (8.49%) and Hausner Ratio (1.09), and the most consistent
weight uniformity (1.28% CV). Drug content uniformity for EMF1 was exceptionally high (99.98 ± 1.79%),
ensuring accurate dosing.
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