Design and development of a polyherbal formulation containing gymnema sylvestre, momordica charantia, and trigonella foenum-graecum for the treatment of diabetes mellitus
DOI:
https://doi.org/10.48047/k6cfxh46Keywords:
Polyherbal formulation, Gymnema sylvestre, Momordica charantia, Trigonella foenumgraecum, Diabetes mellitusAbstract
Introduction: Hyperglycemia, or high blood sugar levels, that do not go down despite insulin treatment is
the hallmark of diabetes mellitus, a metabolic disease that can last for years. The purpose of this research
is to create a polyherbal remedy for diabetes mellitus that includes Gymnema sylvestre, Momordica
charantia, and Trigonella foenum-graecum. These medicinal plants have antidiabetic qualities, which
include reducing glucose levels, making insulin more effective, and protecting pancreatic β-cells.
Materials and Methods: The polyherbal formulation was made with optimised ratios of standardised
extracts of T. foenum-graecum, G. sylvestre, and M. charantia. It was determined that bioactive
components were present through phytochemical analysis. The formulation was tested for its ability to
inhibit α-amylase and α-glucosidase in vitro to determine its antidiabetic effectiveness. To further evaluate
its hypoglycemic potential, an in vivo investigation was conducted in diabetic rats produced with
streptozotocin. The effectiveness was assessed by analysing biochemical indicators, such as lipid profiles
and fasting blood glucose levels
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