Synthesis, characterization and evaluation of potential of antimicrobial of triazolothiadiazines analogues
DOI:
https://doi.org/10.48047/cktrrz88Keywords:
Antimicrobial, triazolothiadiazines, β-ketoester, Synthesis, NMR, IRAbstract
A number of novel thiadizine derivatives with triazole nucleus using a solvent-free,
environmentally friendly process because these heterocycles are significant in many ways for
biology. To find strong physiologically active compounds, we characterised and screened the
synthesised compounds for biological activity. It covers spectrum analysis and the synthesis of
triazolo thiadiazine derivatives. A structurally diverse novel series of triazolothiadiazine derivative
heterocycles with a medicinally preferred nucleus has been produced using simple, solvent-free,
and ecologically safe methods. It was heated in a microwave without using any solvents and mixed
with triazolo Thiol and β-ketoester, and a catalytic amount of hydrazine hydrate. DMF was used as
an energy transfer agent to get a high yield of the product
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