MicroRNA Regulation in Oxidative Stress-Driven Mental Disorders: A Molecular Perspective
DOI:
https://doi.org/10.48047/8f7z7b56Keywords:
miRNA, Oxidative Stress, Mental Disorders, Depression, NeuroinflammationAbstract
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to target
messenger RNAs, leading to their degradation or translation inhibition. Recent research has revealed
the critical role of miRNAs in oxidative stress-associated mental disorders, which include depression,
schizophrenia, bipolar disorder, and Alzheimer's disease. Oxidative stress, characterized by an
imbalance between reactive oxygen species (ROS) and antioxidant defenses, is a key contributor to
neuronal damage, neuroinflammation, and mitochondrial dysfunction—hallmarks of these disorders.
miRNAs such as miR-34a, miR-137, miR-132, miR-146a, and miR-9 regulate oxidative stress
pathways, influencing antioxidant defense systems, mitochondrial function, and neuroinflammation.
For example, miR-34a downregulates the expression of antioxidant genes, exacerbating oxidative
damage, while miR-137 and miR-132 are linked to mitochondrial dysfunction, impacting cognitive
function and mood regulation.
Downloads
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
