Design and Characterization of In-Situ Gelling Hydrocortisone Oromucosal Formulations: A Study of Physical Attributes and Drug Delivery
DOI:
https://doi.org/10.48047/k5ftdj74Keywords:
Oromucosal Delivery, In Situ Gelation, Mucoadhesion, Polymer Formulations, Controlled Release.Abstract
The development of in situ gelling hydrocortisone formulations for oromucosal drug delivery offers a
promising approach to overcoming the challenges associated with short drug retention, poor
bioavailability, and frequent dosing in the treatment of oral inflammatory disorders such as ulcers,
gingivitis, and lichen planus. This study focuses on the design, characterization, and evaluation of
hydrocortisone-loaded in situ gelling systems formulated using Hydroxypropyl Methylcellulose (HPMC),
Carbopol 934, and Sodium Alginate to enhance mucoadhesion, controlled release, and formulation
stability. The formulations were analyzed for pH compatibility, viscosity, gelation time, mucoadhesive
strength, in vitro drug release, and stability over three months. Results demonstrated that HPMC-based
formulations exhibited superior viscosity, mucoadhesion, and sustained drug release, making them the
most promising candidates for prolonged oromucosal retention
Downloads
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
