Phytochemical screening and Analgesic activity of methanolic extract of Portulaca grandiflora on mice

Authors

  • Bhanu Namdev, Dr. Har Govind Garg, Dr. Priyanka Namdeo, Dr. Mehta Parulben D Author

DOI:

https://doi.org/10.48047/6ds1af83

Keywords:

Analgesic, Hot Plate Method, Pentazocine, Portulaca grandiflora

Abstract

The plant Portulaca grandiflora belongs to the family Portulacaceae, a plant native to southern Brazil, Argentina, and Uruguay that is frequently cultivated in gardens. It is also known as Moss rose, Mexican rose and Eleven o'clock. The present study aimed to explore the Analgesict activity is evaluated by by Hot Plate Method, Tail Immersion Test and Acetic Acid Induced Writhing model.
The methanolic extracts of Portulaca grandiflora on mice (200mg/kg & 400mg/kg) produced dose dependent. Among the two doses, 400 mg/kg showed maximum analgesic activity at reaction time 120 min (7.2±0.44) is slightly lower than the standard drug pentazocine (9.9±0.34) in this analgesic testing model, pentazocine significantly prolonged the reaction time of animals with relatively extended duration of stimulation, confirming centrally active drugs. In the present study, all extracts showed significant (p< 0.01) analgesic activity but among the two doses, 400 mg/kg showed highest analgesic activity at reaction time 120 min. Results demonstrated that PGE exhibited a potent dose dependent analgesic activity in all tested models for analgesia.

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References

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Published

2025-02-03

Issue

Vol. 54 No. 3 (2025): Year 2025, Volume 54, Issue 3

Section

Articles

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How to Cite

Phytochemical screening and Analgesic activity of methanolic extract of Portulaca grandiflora on mice (Bhanu Namdev, Dr. Har Govind Garg, Dr. Priyanka Namdeo, Dr. Mehta Parulben D , Trans.). (2025). Cuestiones De Fisioterapia, 54(3), 2576-2583. https://doi.org/10.48047/6ds1af83