Optimization of Transdermal Patches Formulation of Leflunomide for Drug Release and Swelling Index Using Box-Behnken Statistical Design
DOI:
https://doi.org/10.48047/47sad127Keywords:
Box-Behnken design, HPMC, EC, DBP, drug release, swelling index, film formulation.Abstract
The study investigates the effects of varying concentrations of Hydroxypropyl
Methylcellulose (HPMC), Ethylcellulose (EC), and Dibutyl Phthalate (DBP) on the drug
release profile and swelling index of film formulations. A Box-Behnken design was
employed to evaluate the interaction of these formulation factors. The results indicate
that the concentration of HPMC, EC, and DBP significantly influences both the
mechanical properties and the drug release characteristics of the films. These findings
provide insight into the optimization of film formulations for controlled drug delivery
applications.
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