Molecular Mechanisms from Insulin-Mimetic Effect of Vitamin D: Treatment Alternative in Type 2 Diabetes Mellitus
DOI:
https://doi.org/10.48047/76t7bj65Keywords:
Vitamin D and insulin signaling, Bifidobacterium, Insulin-mimetic effect, Type 2 Diabetes Mellitus (T2DM), Glucose metabolism, Pancreatic β-cell function, Vitamin D receptor (VDR), Insulin resistance, Glucose homeostasisAbstract
Type 2 Diabetes Mellitus (T2DM) is a complex metabolic disorder characterized by insulin resistance and beta-cell dysfunction. Recent research highlights the role of vitamin D in glucose homeostasis and its potential insulin-mimetic effects. This review explores the molecular mechanisms by which vitamin D enhances insulin sensitivity, preserves beta-cell function, and modulates inflammatory and oxidative stress pathways.
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References
Pittas, A.G.; Kawahara, T.; Jorde, R.; Dawson-Hughes, B.; Vickery, E.M.; Angellotti, E.; Nelson, J.; Trikalinos, T.A.; Balk, E.M. (2023). Vitamin D and risk for type 2 diabetes in people with prediabetes: a systematic review and meta-analysis of individual participant data from 3 randomized clinical trials. Annals of Internal Medicine, 176(3),355–363. 2. Dashti, F.; Mousavi, S.M.; Larijani, B.; Esmaillzadeh, A. (2021). The effects of vitamin D supplementation on inflammatory biomarkers in patients with abnormal glucose homeostasis: A systematic review and meta-analysis of randomized controlled trials. Pharmacol. Res. 170, 105727
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