"IN SILICO ANALYSIS OF ANTIMICROBIAL ACTIVITY IN NOVEL PYRIMIDINOL DERIVATIVES"

Authors

  • Meenakshi Tyagi Department of Pharmaceutical Sciences, Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur, UP Author
  • Mukesh Maithani Department of Pharmaceutical Sciences, HNB Garhwal University, Srinagar Garhwal, U.K. Author
  • Mayank Yadav Department of Pharmaceutical Sciences, Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur, UP Author

DOI:

https://doi.org/10.48047/cu/54/03/1880-1894

Keywords:

Ciprofloxacin, Antibacterial, molecular docking, Pyrazole- Pyrimidine

Abstract

The burgeoning of resistance to antimicrobial drugs is a key the ample defence behind continued research into new compounds. Ciprofloxacin (CPFX) was chosen as standard compound, a virtual screening refinement was appliance to examine the interaction between the compound and its potential targets. Compounds that showed stronger interactions with the target than Ciprofloxacin (CPFX) were selected for further development. The in - silico analysis of these compounds suggested they had drug-like properties and demonstrated good bioactivity and pharmacokinetic properties. Fifteen derivatives of Pyrazol- pyrimidine were synthesized 
and confirmed by using molecular docking techniques.[1]The process of molecular docking, which involves the arrangement of new Pyrazol- pyrimidine derivatives drawn by Chem Draw 3D (version 16.0) was constitute at the subatomic level by using conventional bond lengths and angles. 

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References

Redhwan, Moqbel Ali Moqbel, Gitima Deka, and Melvin Mariyam Varghese. "Synthesis and Molecular docking studies of some new Pyrazoline derivatives for Antimicrobial properties." Research Journal of Pharmacy and Technology 13, no. 10 (2020): 4629-4634.

DOI: 10.5958/0974-360X.2020.00815.X

Padmaja, A., T. Payani, G. Dinneswara Reddy, and VJEJoMC Padmavathi. "Synthesis, antimicrobial and antioxidant activities of substituted pyrazoles, isoxazoles, pyrimidine and thioxopyrimidine derivatives." European Journal of Medicinal Chemistry 44, no. 11 (2009): 4557-4566. DOI: 10.1016/j.ejmech.2009.06.024

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Published

2025-02-03

Issue

Vol. 54 No. 3 (2025): Year 2025, Volume 54, Issue 3

Section

Articles

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How to Cite

"IN SILICO ANALYSIS OF ANTIMICROBIAL ACTIVITY IN NOVEL PYRIMIDINOL DERIVATIVES" (M. Tyagi, M. . Maithani, & M. Yadav , Trans.). (2025). Cuestiones De Fisioterapia, 54(3), 1880-1894. https://doi.org/10.48047/cu/54/03/1880-1894