Formulation and Evaluation of Gastroretentive Floating Beads of Valsartan
DOI:
https://doi.org/10.48047/9c0tgf60Keywords:
Floating Drug Delivery System, Floating Beads, Inotropic gelatin method, Valsartan, Hypertension.Abstract
Background: This study focuses on the formulation and optimization of floating calcium pectinate beads encapsulating valsartan, a BCS Class II drug with poor aqueous solubility and low oral bioavailability. Method: Floating drug delivery systems were developed using the inotropic gelation technique, incorporating low methoxy pectin (primary polymer), gellan gum (release modifier),
sodium bicarbonate (gas-generating agent), and calcium chloride (cross-linking agent). A 2³ factorial design was employed to optimize three independent variables: the ratio of pectin to gellan gum, sodium bicarbonate concentration, and calcium chloride concentration, with the goal of achieving prolonged gastric retention, high drug entrapment efficiency, and controlled drug release.
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References
Turac, I. R., Porfire, A., Iurian, S., Crișan, A. G., Casian, T., Iovanov, R., & Tomuță, I. (2024). Expanding the Manufacturing Approaches for Gastroretentive
Drug Delivery Systems with 3D Printing Technology. Pharmaceutics, 16(6), 790. https://doi.org/10.3390/pharmaceutics16060790
Tripathi, J., Thapa, P., Maharjan, R., & Jeong, S. H. (2019). Current State and Future Perspectives on Gastroretentive Drug Delivery Systems. Pharmaceutics, 11(4), 193. https://doi.org/10.3390/pharmaceutics11040193
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