FORMULATION AND CHARACTERIZATION OF HYDRODYNAMICALLY BALANCED DELIVERY SYSTEM OF MIGLITOL FOR PROLONGED GASTRIC RETENTION IN TYPE-2 DIABETES

Authors

  • Senthil Rajan Dharmalingam, Battula Sowjanya Lakshmi, Prasanta Kumar Choudhury, Kiran Bhausaheb Dhamak, Abdul Rahamanulla, Pooja Devi, Suryanarayan Dash, Meman Rahil Salim Author

DOI:

https://doi.org/10.48047/jtt86919

Keywords:

Miglitol Sustained Release, In Vitro Drug Release, Hydrodynamically Balanced System (HBS), Micromeritic Properties, Release Kinetics Models

Abstract

The objective of the current study was to create and assess a hydrodynamically balanced system (HBS) for miglitol in order to achieve sustained drug release and extended stomach retention. Five formulations (HBSF1 to HBSF5) were prepared using Modified Methylcellulose Hydrogel (MMCH) and Xanthan Gum (XG) as hydrophilic polymers, ensuring controlled drug release and enhanced buoyancy. The micromeritic properties of the formulations were evaluated, demonstrating excellent flowability, compressibility, and uniform weight distribution, with Carr’s Index (≤3.48%), Hausner Ratio (~1.02–1.03), and an Angle of Repose below 25°, ensuring efficient capsule filling and manufacturing reproducibility. 

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References

Bantounou, M. A., Sardellis, P., Plascevic, J., Awaes-Mahmood, R., Kaczmarek, J., Black Boada, D., Philip, S. (2024). Meta-analysis of sotagliflozin, a dual sodium-glucose cotransporter 1/2 inhibitor, for heart failure in type 2 diabetes. ESC Heart Fail. doi:10.1002/ehf2.15036

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Published

2025-02-03

Issue

Vol. 54 No. 3 (2025): Year 2025, Volume 54, Issue 3

Section

Articles

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How to Cite

FORMULATION AND CHARACTERIZATION OF HYDRODYNAMICALLY BALANCED DELIVERY SYSTEM OF MIGLITOL FOR PROLONGED GASTRIC RETENTION IN TYPE-2 DIABETES (Senthil Rajan Dharmalingam, Battula Sowjanya Lakshmi, Prasanta Kumar Choudhury, Kiran Bhausaheb Dhamak, Abdul Rahamanulla, Pooja Devi, Suryanarayan Dash, Meman Rahil Salim , Trans.). (2025). Cuestiones De Fisioterapia, 54(3), 1771-1787. https://doi.org/10.48047/jtt86919