Development and Validation of a Novel Eco-friendly green Stability indicating RP- HPLC-PDA Method for the Simultaneous Quantification of Remogliflozin etabonate and Metformin HCl in Pharmaceutical Dosage Forms
DOI:
https://doi.org/10.48047/rha65s16Keywords:
.Abstract
The project sought to establish and test an environmentally friendly stability indicating RP HPLC method for parallel quantification of Remogliflozin etabonate and Metformin HCl in their pharmaceutical combination dosage forms according to ICH guidelines. The analysis utilized Phenomenex C18 (250 mm × 4.6 mm, 5 µ) as the chromatographic column with a 45:55% v/v ratio of 0.02 M phosphate buffer (pH 3.5 adjusted with 1% OPA) and acetonitrile as the mobile phase and it operated at 1.0 mL/min through a PDA detector which found both medications and their degradant products had excellent peak separation at 245nm.
Downloads
References
Rang, H. P., Dale, M. M., Pitter, J. M., & Flower, R. J. (2007). Pharmacology (6th ed.). Elsevier.
Goyal, R. K. (2009). Elements of Pharmacology (19th ed.). B. S. Shah Prakashan. Indian Pharmacopoeia Commission. (2010).
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
