“Protective Effects of Swertia chirayata Extract Against Doxorubicin Induced Hepatotoxicity: Molecular Insights and Translational Implications”
DOI:
https://doi.org/10.48047/82ntsh13Keywords:
Doxorubicin, hepatotoxicity, Swertia chirayata, oxidative stress, apoptosis, inflammation.Abstract
Doxorubicin (DOX) is a widely used chemotherapeutic agent associated with severe hepatotoxicity due to oxidative stress, inflammation, and apoptosis. The present study evaluates the hepatoprotective effects of Swertia chirayata extract against DOX-induced liver toxicity in Wistar albino rats. Rats were divided into four groups: Control, DOX-only, Swertia chirayata
(200 mg/kg), and Swertia chirayata (400 mg/kg). The study assessed biochemical parameters (ALT, AST, ALP, bilirubin), oxidative stress markers (MDA, SOD, GSH), and histopathological changes.
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References
Aviles, A., et al. Doxorubicin-induced hepatotoxicity: An overview. Cancer Chemother Pharmacol. 1984;12(2):87-90.
Bains, S., et al. Cytochrome P450 and carbonyl reductases in doxorubicin metabolism. Drug Metab Rev. 2010;42(3):394-407.
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