Exploring Cyclooxygenase-2 (COX-2) Inhibitors From Ascidian Derived Ligands For Cancer Treatment: An In-Silico Study.
DOI:
https://doi.org/10.48047/CU/54/02/3320-3333Keywords:
.Abstract
Cancer remains a significant global health challenge with increasing mortality rates expected in the coming years. Inflammation plays a crucial role in cancer progression, and cyclooxygenase-2 (COX-2) has been identified as a key target for cancer therapy. COX-2 is overexpressed in several cancers and contributes to cancer progression through inflammatory pathways. The therapeutic potential of selective COX-2 inhibitors, such as those derived from non-steroidal anti-inflammatory drugs (NSAIDs), has been widely recognized, although concerns about cardiovascular risks persist.
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