Medicinal Chemistry of Kinase Inhibitors: A Review of Recent Advances
DOI:
https://doi.org/10.48047/fn4kxt03Keywords:
Kinase inhibitors, medicinal chemistry, targeted therapy, cancer treatment, ATP-competitive inhibitors, allosteric inhibitors.Abstract
Kinase inhibitors have emerged as pivotal therapeutic agents due to their ability to target and modulate the activity of kinases, enzymes that regulate crucial cellular processes through phosphorylation. Dysregulated kinase activity is implicated in various diseases, particularly cancer, making kinase inhibitors an essential class of drugs in modern medicine.
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References
Manning, G., Whyte, D. B., Martinez, R., Hunter, T., & Sudarsanam, S. The protein kinase complements of the human genome. Science, 2002, 298(5600), 1912-1934. 2. Cohen, P. Protein kinases—the major drug targets of the twenty-first century? Nature Reviews Drug Discovery, 2002, 1(4), 309-315.
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