Predictor biomarkers for cognitive impairment in Temporal Lobe Epilepsy in adults

Authors

  • Ibrahim M. Abdelazeem, Azza Elmongui,Mervat Mashaly, Nehal Tharwat, Shimaa Elgamal, Wessam Mustafa, Author

DOI:

https://doi.org/10.48047/x5rf8a93

Keywords:

HMGB1, temporal lobe epilepsy, cognitive impairment

Abstract

Background: The most frequent cause for focal seizures is temporal lobe epilepsy (TLE). The temporal lobe is primarily responsible for speech, memory, learning, and affective behavior. The previously mentioned functions would be disrupted if the lobe's internal structures were damaged. 
Aim: To determine cognitive impairment in TLE in adults and to investigate if there was an association between serum levels of HMGB1 and S100B expressions with cognitive impairment in TLE for the possibility of detecting predictive biomarkers for cognitive 
impairment in TLE. 

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References

Vrinda M, Arun S, Srikumar BN, Kutty BM, Shankaranarayana Rao BS. Temporal lobe epilepsyinduced neurodegeneration and cognitive deficits: Implications for aging. Journal of Chemical Neuroanatomy. 2019;95:146-53.

Knierim JJ. The hippocampus. Current Biology. 2015;25(23):R1116-R21.

Riley JD, Franklin DL, Choi V, Kim RC, Binder DK, Cramer SC, et al. Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles. Epilepsia. 2010;51(4):53645.

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Published

2025-02-03

How to Cite

Ibrahim M. Abdelazeem, Azza Elmongui,Mervat Mashaly, Nehal Tharwat, Shimaa Elgamal, Wessam Mustafa,. (2025). Predictor biomarkers for cognitive impairment in Temporal Lobe Epilepsy in adults . Cuestiones De Fisioterapia, 54(3), 151-172. https://doi.org/10.48047/x5rf8a93