Development and validation of simple UV spectrophotometric method for estimation of Itopride Hydrochloride in bulk and tablet dosage form
DOI:
https://doi.org/10.48047/42yh4702Keywords:
Itopride hydrochloride, Method development, UV spectroscopy, Validation.Abstract
A simple, precise and economical spectroscopic method developed for estimation of itopride hydrochloride from bulk drug and tablet dosage form. The UV spectrum of itopride hydrochloride in 0.1NHCl showed λmax at 258 nm. This method was validated for
linearity, accuracy, precision, robustness, limit of detection, limit of quantitation. This method showed good linearity in the concentration range of 5-30µg/ml, (obey’s BeerLambert’s law) with regression coefficient (r2) 0.9995. The recovery was found in the range 110.61 % to 100.88%. Limit of detection (DL) and Limit of quantitation (QL) were found to be 0.69µg/ml and 2.1µg/ml respectively. From results it can be concluded that developed method can be used for analysis of itopride hydrochloride.
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References
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