Investigating the Role of IFN-γ, IL-1β, IL-10, and GM-CSF in the Pathophysiology of Chronic Gastritis: Clinical Correlations and Immunological Assessments
DOI:
https://doi.org/10.48047/6c9wn836Keywords:
Chronic gastritis, Helicobacter pylori, urea breath test (UBT), H. pylori stool antigen (HP S-Ag), IFN-γ, IL-1β, IL-10, GM-CSF.Abstract
Background: Chronic gastritis is a prevalent gastrointestinal condition often associated with Helicobacter pylori (H. pylori) infection and influenced by lifestyle factors such as diet, obesity, alcohol consumption, stress, pain relievers abuse and smoking. Here, we investigated the role of cytokines in pathophysiology of the disease, and evaluated the diagnostic efficacy of urea breath test (UBT) and H. pylori stool antigen (HP S-Ag) tests.
Methods: A cohort of 125 patients with chronic gastritis and a control group (27 participants) were analysed. Demographic data and clinical symptoms were collected. H. pylori test using UBT and H.P S-Ag was conducted. Serum cytokine levels (IFN-γ, IL-1β, IL-10, and GM-CSF) were measured. The diagnostic performance of UBT and H.P S-Ag was evaluated and Spearman’s correlation analysis was conducted to determine association between the cytokines measured and UBT delta over baseline (DOB) values as well as
H.P S-Ag levels.
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References
Sokolova, O. and M. Naumann, Matrix metalloproteinases in Helicobacter pylori Associated gastritis and gastric cancer. International Journal of Molecular Sciences, 2022. 23(3): p. 1883.
Varbanova, M., K. Frauenschläger, and P. Malfertheiner, Chronic gastritis–an update. Best Practice & Research Clinical Gastroenterology, 2014. 28(6): p. 1031-1042.
Al-Jameel, H.H., et al., Autoimmune Hepatitis: Evaluation of Clinical Presentation, Diagnosis and Response to Treatment in Iraqi Patients. Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138), 2021. 53(4): p. 104-113.
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