Formulation Of Zingiber Officinale Essential Oil Based Nanoemulsion And Evaluation of Its Neuroprotective Effect Against Hydrogen Peroxide Induced Cytotoxicity In SH-SY5Y Cell Line
DOI:
https://doi.org/10.48047/7kds0427Keywords:
Zingiber officinale, nanoemulsion, particle size, SHSY5Y cell line, neurodegenration.Abstract
The increasing prevalence of neurodegenerative disease underscores the immediately need for effective treatment of neuronal cell death. Free radical scavaning is a major drawback for neurodegenerative disorder. The aim of current study is to preparation of nanoemuslion using surfactant tween 80, water and ginger essential oil rich in zingiberene and also to evaluate the neuroprotective potential of Zingiber officinale nanoemulsion against Hydrogen Peroxide induced cytoxicity in SHSY5Y cell line, essential oil renowned for their antioxidant and anti inflammatory properties.
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References
Alaqeel, N. K., AlSheikh, M. H., & Al-Hariri, M. T. (2022). Quercetin nanoemulsion ameliorates neuronal dysfunction model. Antioxidants, 11(10), 1986.
in experimental Alzheimer’s disease
Md, S., Gan, S. Y., Haw, Y. H., Ho, C. L., Wong, S., & Choudhury, H. (2018). In vitro neuroprotective effects of naringenin nanoemulsion against β-amyloid toxicity through the regulation of amyloidogenesis and tau phosphorylation. International Journal of Biological Macromolecules, 118, 1211-1219.
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