STUDY OF SIGNIFICANCE OF MAST CELLS IN IDENTIFYING MICROINVASION IN NON NEOPLASTIC LESIONS OF UTERUS.
DOI:
https://doi.org/10.48047/5wkfws16Keywords:
Leiomyoma, Mast cells, mast cell density, myometrium, smooth muscle tumorAbstract
Background: Mast cells are myeloid immune cells that take part in various physiological and pathological processes in our body. Their role in initiating angiogenetic mechanisms and in promoting tissue remodeling of neoplasms along with the prognostic significance of their presence in various tumors is still not completely understood. Mast cells have been noted in myometrium and observed in association with smooth muscle tumors of the uterus. This study attempts to study their role in Leiomyomas. Objectives: 1. To compare the mast cell density in leiomyomas of the uterus with the adjacent myometrium.2. To compare the mast cell density in various degenerations in leiomyoma.3. To compare the percentage of mast cell index in leiomyomas and adjacent myometrium.
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References
Apurva V, Pradeep S, Manchanda G S et al. Mast cell profile in myometrial lesions: a study of 577 cases. Indian Journal of Basic and Applied Medical Research; March 2016: Vol.-5, Issue- 2, P. 64650.
Kalyani R, Rajeshwari G. Significance of Mast cells in Non-neoplastic and Neoplastic lesions of Uterine Cervix. Biomedical Research and Therapy2016; 3(1): 469-75.
Komi DE, Redegeld FA. Role of mast cells in shaping the tumor microenvironment. Clinical reviews in allergy & immunology. 2020 Jun;58(3):313-25.
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