Formulation and Evaluation of oil Based PLGA Hybrid Nanocarrier for Highly Lipophilic Drug
DOI:
https://doi.org/10.48047/q848ab56Keywords:
Hybrid polymeric nanocarriers, PLGA, lipophilic drug, vegetable oil.Abstract
Objectives:
The study's objective was to create and assess a biocompatible PLGA-oil hybrid for high loading and regulated distribution of lipophilic drugs utilizing the solvent evaporation method. PLGA nanoparticles and synthetic/vegetable oils are combined in this formulation to improve stability, adaptability, size homogeneity, drug loading, and therapeutic effectiveness. A unique approach to drug delivery systems is represented by hybrid nanoparticles that combine PLGA with either synthetic or vegetable oils.
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References
Whitman J, Stan R, Cecoltan S, Chifiriuc MC, Iovu H. Hybrid nanocarriers based on PLGA vegetable oil: A novel approach for high drug delivery. Journal of Drug Delivery Science and Technology. 2018 Aug 1; 46:162-72.
Whitman J, Biru EI, Stan R, Iovu H. Review of hybrid PLGA nanoparticles: Future of smart drug delivery and theranostics medicine. Materials & Design. 2020 Aug 1; 193:108805.
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