Hypomagnesemia and Acute Kidney Injury in Critical Illness: Pathophysiology, Prognostic Value, and Clinical Implications
DOI:
https://doi.org/10.48047/hrdjm969Keywords:
acute kidney injury; critical illness; hypomagnesemia; intensive care unit; serum magnesiumAbstract
Background: Acute kidney injury (AKI) is common in critical illness and remains difficult to detect before clinically apparent loss of filtration. Magnesium is central to cellular energy handling, vascular tone, inflammatory signaling, and tubular transport. Hypomagnesemia is frequent in intensive care and has been associated with AKI, but its clinical interpretation is complicated by illness severity, medications, renal losses, and the limitations of total serum magnesium measurement.
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References
Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012;2(1):1-138.
Kellum JA, Romagnani P, Ashuntantang G, Ronco C, Zarbock A, Anders HJ. Acute kidney injury. Nat Rev Dis Primers. 2021;7(1):52.
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