Beyond Body Mass Index in Colorectal Cancer: Body Composition, Metabolic Phenotypes, and Precision Risk Stratification
DOI:
https://doi.org/10.48047/z5qazz45Keywords:
Colorectal cancer, Body composition, Sarcopenia, Visceral adiposity, Obesity paradoxAbstract
Background: Body mass index (BMI) is the most widely used measure of adiposity in oncology, yet it cannot distinguish visceral
fat from subcutaneous fat, skeletal muscle from adipose tissue, or stable obesity from cancer-associated weight loss. These limitations are clinically important in colorectal cancer
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References
Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in
countries. CA Cancer J Clin. 2024;74(3):229-263.
Moghaddam AA, Woodward M, Huxley R. Obesity and risk of colorectal cancer: a meta-analysis of 31 studies with 70,000 events. Cancer Epidemiol
Biomarkers Prev. 2007;16(12):2533-2547.
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