CLINICAL PROFILE AND IMMEDIATE OUTCOME OF NEONATAL SEPSIS IN A TERTIARY CARE NEONATAL INTENSIVE CARE UNIT: A PROSPECTIVE OBSERVATIONAL STUDY

Authors

  • Dr. Usha Rani Hasthi A Author
  • Dr. Kesam Reddy Swetha A Author

DOI:

https://doi.org/10.48047/t51mmt24

Keywords:

neonatal sepsis; blood culture; early-onset sepsis; NICU; outcome; South India

Abstract

Background: Neonatal sepsis is a leading cause of neonatal mortality in developing countries. Characterising its clinical profile, bacteriology and immediate outcome guides empirical therapy and care. Objectives: To describe the clinical profile, risk factors, bacteriological spectrum and immediate outcome of neonates with sepsis admitted to a tertiary neonatal intensive care unit (NICU). Methods: A prospective observational study of 100 neonates with clinically suspected or culture-confirmed sepsis recorded perinatal risk factors, clinical features, sepsis screen, blood culture, complications and outcome. Groups (early- vs late-onset) were compared descriptively. Results: Of 100 neonates (55% male; mean gestation 36.6 ± 3.0 weeks; mean birth weight 2663 ± 633 g), 54% had early-onset and 46% late-onset sepsis. Poor feeding (100%), lethargy (76%) and respiratory distress (57%) were the commonest features. Blood culture was positive in 33%; the leading isolates were Staphylococcus aureus (11), Group B Streptococcus (10), Escherichia coli (5), Acinetobacter species (4) and Klebsiella pneumoniae (3). Shock occurred in 14% and mechanical ventilation was required in 20%; mean stay was 14.5 ± 6.1 days. Overall, 74% were discharged alive, 23% transferred and 3% died. Conclusion: Neonatal sepsis presented with non-specific features, a culture-positivity rate of one-third dominated by S. aureus and Gram-negative organisms, and low immediate mortality with intensive care. The findings support a high index of suspicion, prompt sepsis screening and locally informed empirical antibiotic choice.

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Published

2020-09-12

Issue

Vol. 49 No. 3 (2020): Year 2020, Volume 49, Issue 3

Section

Original

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How to Cite

CLINICAL PROFILE AND IMMEDIATE OUTCOME OF NEONATAL SEPSIS IN A TERTIARY CARE NEONATAL INTENSIVE CARE UNIT: A PROSPECTIVE OBSERVATIONAL STUDY (D. U. R. H. A & D. K. R. S. A , Trans.). (2020). Cuestiones De Fisioterapia, 49(3), 407-413. https://doi.org/10.48047/t51mmt24