Beyond Glycemic Control: SGLT2 Inhibitors as Modulators of Post-Infarction Myocardial Remodeling

Authors

  • Shaimaa Wageeh, Tarek Ahmed Naguib, Amr Salah Taha Hassanin, Alaa Elsayed Salama Author

DOI:

https://doi.org/10.48047/vkm71r84

Keywords:

SGLT2 inhibitors, myocardial infarction, ventricular remodeling, heart failure

Abstract

Background: Acute myocardial infarction initiates a dynamic process of structural, functional, metabolic, and molecular adaptation that may culminate in adverse left ventricular remodeling and subsequent heart failure despite successful contemporary reperfusion. Sodium–glucose cotransporter-2 inhibitors were originally introduced as glucose-lowering agents; however, their consistent cardiovascular and renal benefits in populations with heart failure and chronic kidney disease have generated substantial interes

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References

Byrne RA, Rossello X, Coughlan JJ, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2023;44(38):3720-3826. doi:10.1093/eurheartj/ehad191.

Verma S, McMurray JJV. SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review. Diabetologia. 2018;61(10):2108-2117. doi:10.1007/s00125-018-4670-7.

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Published

2024-11-20

Issue

Vol. 53 No. 03 (2024): Year 2024, Volume 53, Issue 3

Section

Original

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How to Cite

Beyond Glycemic Control: SGLT2 Inhibitors as Modulators of Post-Infarction Myocardial Remodeling (Shaimaa Wageeh, Tarek Ahmed Naguib, Amr Salah Taha Hassanin, Alaa Elsayed Salama , Trans.). (2024). Cuestiones De Fisioterapia, 53(03), 8367-8376. https://doi.org/10.48047/vkm71r84