DOG1/ANO1 in Breast Pathology: Diagnostic Utility, Interpretive Pitfalls, and Biological Significance
DOI:
https://doi.org/10.48047/q462xx09Keywords:
DOG1; ANO1; myoepithelial cells; breast pathology; invasionAbstract
Background: Demonstration of the myoepithelial cell layer is central to separating benign and in-situ breast proliferations from invasive carcinoma. Conventional markers are valuable but imperfect because staining may be attenuated in ductal carcinoma in situ, duplicated by tumor cells, or obscured by stromal and vascular cross-reactivity. DOG1, the immunohistochemical surrogate of the calcium-activated chloride channel ANO1/TMEM16A, has emerged as a complementary breast myoepithelial marker.
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References
Bachert SE, Chapel E, Schnitt SJ. Breast myoepithelial markers: problems and pitfalls for the practicing pathologist. Hum Pathol. 2025;162:105909.
Rakha EA, Miligy IM, Gorringe KL, Toss MS, Green AR, Fox SB, et al. Invasion in breast lesions: the role of the epithelial stroma barrier. Histopathology. 2018;72(7):1075-1083.
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