The CXCL5/CXCR2 Axis in Urothelial Bladder Carcinoma: Mechanistic Biology, Biomarker Evidence, and Therapeutic Prospects

Authors

  • Alaa Nagy Abdou Mousa, Mona Mohamed El-Sayed, Abeer Mohamed Abd-Elbary, Maha Ahmed Mahmoud Author

DOI:

https://doi.org/10.48047/r6hq1819

Keywords:

bladder cancer; CXCL5; CXCR2; chemokines; tumor microenvironment

Abstract

Background: Urothelial bladder carcinoma is heterogeneous, and conventional clinicopathological variables incompletely explain recurrence, progression, and treatment resistance. C-X-C motif chemokine ligand 5 (CXCL5), which predominantly signals through CXCR2, may link  malignant urothelial cells with vascular and myeloid compartments. 

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References

Filho AM, Laversanne M, Ferlay J, Colombet M, Piñeros M, Znaor A, et al. The GLOBOCAN 2022 cancer estimates: data sources, methods, and a snapshot of the cancer burden worldwide. Int J Cancer. 2025;156(7):13361346.

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Published

2024-11-20

Issue

Vol. 53 No. 03 (2024): Year 2024, Volume 53, Issue 3

Section

Original

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How to Cite

The CXCL5/CXCR2 Axis in Urothelial Bladder Carcinoma: Mechanistic Biology, Biomarker Evidence, and Therapeutic Prospects (Alaa Nagy Abdou Mousa, Mona Mohamed El-Sayed, Abeer Mohamed Abd-Elbary, Maha Ahmed Mahmoud , Trans.). (2024). Cuestiones De Fisioterapia, 53(03), 8252-8258. https://doi.org/10.48047/r6hq1819