α-Lipoic Acid and Vitamin C in Isoprenaline-Induced Myocardial Injury: Physiological Mechanisms and Cardioprotective Potential
DOI:
https://doi.org/10.48047/aascmz87Keywords:
α-Lipoic acid, Ascorbic acid, Isoprenaline, Myocardial injury, Oxidative stressAbstract
Background:: Isoprenaline-induced myocardial injury is a reproducible experimental model used to investigate the biochemical and cellular consequences of excessive β-adrenergic stimulation. At high doses, isoprenaline markedly increases cardiac workload and undergoes auto-oxidation, initiating reactive oxygen species generation, lipid peroxidation, calcium dysregulation, mitochondrial impairment, inflammation, and cardiomyocyte death. These interconnected abnormalities resemble important components of acute myocardial injury, although the model does not reproduce coronary atherothrombosis in humans.
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References
Martin TP, MacDonald EA, Elbassioni AAM, O’Toole D, Zaeri AAI, Nicklin SA, et al. Preclinical models of myocardial infarction: from mechanism to translation. Br J Pharmacol. 2022;179(5):770-91.
Garg M, Khanna D. Exploration of pharmacological interventions to prevent isoproterenol-induced myocardial infarction in experimental models. Ther Adv Cardiovasc Dis. 2014;8(4):155-69
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