Complete Blood Count–Derived Indices in Chronic Lymphocytic Leukemia: Prognostic Significance, Biological Basis, and Clinical Applicability
DOI:
https://doi.org/10.48047/pmp01h38Keywords:
chronic lymphocytic leukemia; complete blood count; prognostic biomarkers; hematologic indices.Abstract
Background: Chronic lymphocytic leukemia is characterized by marked clinical heterogeneity, ranging from indolent disease that may never require treatment to rapidly progressive leukemia associated with early therapeutic intervention and shortened survival. Although established prognostic systems incorporate clinical stage, age, serum beta-2 microglobulin, immunoglobulin heavy-chain variable-region mutational status, and TP53 abnormalities, access to molecular and cytogenetic testing remains unequal across healthcare settings.
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References
Hallek M. Chronic lymphocytic leukemia: 2025 update on the epidemiology, pathogenesis, diagnosis, and therapy. Am J Hematol. 2025;100(3):450-480. doi:10.1002/ajh.27546
International CLL-IPI Working Group. An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI): a meta-analysis of individual patient data. Lancet Oncol. 2016;17(6):779-790. doi:10.1016/S1470-2045(16)30029-8
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