FORMULATION AND EVALUATION OF MICCONAZOLE LOADED TRANSFEROSOME PATCHES TO TREAT FUNGAL DISEASE
DOI:
https://doi.org/10.48047/vjnqa458Keywords:
transferosomes,, patches, miconazole,, evaluationAbstract
The research work was carred out to develop a transferosomalpatchesloaded miconazole for fungal treatment. Variousformulations of transfersomes were prepared and evaluated. Prepared patcheswere prepared and evaluated for pH measurement, weight uniformity, folding endurance, thickness, moisture loss and drug release study, weight uniformity was found that 19.913(mg), folding endurance was found to be>150 , thickness of patches was found to be 138.5(mm), moisture loss was 0.681.By Frans diffusion cell method the drug absorption will be ensured and found to be 227nm.
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Irfan M, Verma S, Ram A. Preparation and characterization of ibuprofen loaded transferosomes as a novel carrier for transdermal drug delivery system. Asian j Pharm. clin resear, 2012; 162-165.
Trommer, H., & Neubert, R. H. H. (2006). Overcoming the stratum corneum: the modulation of skin penetration: a review. Skin pharmacology and physiology, 19(2), 106-121.
El Zaafarany GM, Awad GAS, Holayel SM, Mortada ND. Role of edge activators and surface charge in developing ultra deformable vesicles with enhanced skin delivery. Int J Pharm, 2010; 164-172.
Cevc G, Grbauer D, Schatzlein A, Blume G. Ultraflexible vesicles, transferosomes, have an extremely low pore penetration resistance ant transport therapeutic amounts of insulin across the intact mammalian skin. BiochemBiophys Act, 1998; 201-215.
El-Maghraby GM, Williams AC. Vesicular systems for delivering conventional small organic molecules and larger macromolecules to and through human skin. Expert Opin Drug Deliv, 2009; 149-163.
Walve JR, Bakliwal SR, Rane BR, Pawar SP. Transferosomes: A surrogated carrier for transdermal drug delivery system. Int J App Bio Pharm Tech, 2011; 201-214.
Cevc G, Blume G. Lipid vesicles penetrate into intact skin owing to transdermal osmoticgradient and hydration force. BiochemBiophys Act, 1992; 226-332.
Jain NK. Advances in Controlled and Novel Drug Delivery. CBS Publishers and Distributers First edition2001. New Delhi, 426-451.
Paul, A, Cevec G. Non-invasive Administration of Protein Antigens. Epicutaneous with Bovin Serum Albumine, Vaccine Research, 1998; 145-164.
Bovin Serum Albumine, Vaccine Research, 1998; 145-164. 10. Panchagnula R. “Transdermal delivery of drugs”. Indian Journal Pharmacology, 1997; 140-156.
Cevc G. “Isothermal lipid phase”, Transitions Chemistry and Physics of Lipids, 1991; 293-299.
Modi CD, Bharadia PD. “Transferosomes: New Dominants for Transdermal Drug Delivery”. Am. J. PharmTech Res., 2012; 71-91.
Sheo DM, Shweta A, Vijay KT, Ram CD, Aklavya S, Ghanshyam M. “Enhanced Transdermal delivery of indinavir sulfate via transferosomes”. Pharmacie Globale (IJCP), 2010; 1-7.
Neha Thakur, Prabhat Jain, Vivek Jain. Formulation, development and evaluation of transferosomal gel. Journal of drug delivery and therapeutics, 2018; 8(5): 168-177.
Lei W, Yu C, Lin H, Zhou X (2013). Development of tacrolimus loaded transfersomes for deeper skin penetration enhancement and therapeutic effect improvement in vivo. Asian J Pharm. 8(6),336–345.
Guo F., Wang J., Ma M., Tan F., Li N (2015). Skin targeted lipid vesicles as novel nano-carrier of ketoconazole: characterization, in vitro and in vivo evaluation. J. Mater. Sci. Mater. Med. 26,175.
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