Endothelial Injury Biomarkers in Pediatric Lupus: Focus on Endocan as an Early Predictor of Vascular Dysfunction
DOI:
https://doi.org/10.48047/5wvy0t24Keywords:
Vascular Dysfunction, Endothelial Injury , Pediatric LupusAbstract
Background: Pediatric-onset systemic lupus erythematosus (pSLE) is a chronic multisystem autoimmune disease characterized by heightened disease severity, cumulative organ damage, and increased long-term cardiovascular morbidity compared with adult-onset disease. Endothelial dysfunction represents a critical early event in the pathogenesis of premature atherosclerosis observed in children with lupus, often preceding overt clinical cardiovascular disease. Traditional cardiovascular risk assessment tools are insufficient in pediatric lupus, underscoring
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References
Hersh AO, von Scheven E, Yazdany J, et al. Differences in long-term outcomes between adults and children with systemic lupus erythematosus. Arthritis
Rheum. 2009;61(3):404-412. doi:10.1002/art.24338
Bruce IN. Cardiovascular disease in lupus patients: the role of traditional and lupus-related risk factors. Curr Cardiol Rep. 2005;7(2):85-90.
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