Potential Effects of Liraglutide on Male Reproductive Dysfunction Associated with Obesity
DOI:
https://doi.org/10.48047/kz03d733Keywords:
Liraglutide, Male Reproductive Dysfunction, ObesityAbstract
Background: Obesity is increasingly recognized as an important contributor to male reproductive dysfunction through hormonal imbalance,
insulin resistance, chronic inflammation, oxidative stress, impaired hypothalamic-pituitary-gonadal axis activity, and direct damage to
testicular tissue. These alterations may reduce testosterone production, impair spermatogenesis, decrease sperm quality, and increase the risk of hypogonadism and infertility. Liraglutide, a glucagon-like peptide-1 receptor agonist, is widely used for glycemic control and weight management and may exert additional reproductive benefits through metabolic, anti-inflammatory, antioxidant, and endocrinemechanisms. This review evaluates the potential effects of liraglutide on obesity-associated male reproductive dysfunction
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References
Chamarthi VS, Daley SF. Comprehensive assessment and diagnosis of metabolic and biomechanical complications in obesity. In: StatPearls. StatPearls Publishing; 2025. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459357/
Khanna D, Welch BS, Rehman A. Pathophysiology of obesity. In: StatPearls. StatPearls Publishing; 2022. Available from:
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