SIRT1 as a Molecular Link Between Lifestyle Intervention and Ovarian–Metabolic Dysfunction in Experimental PCOS
DOI:
https://doi.org/10.48047/dtfcz254Keywords:
SIRT1, Molecular , Lifestyle Intervention, Ovarian–Metabolic Dysfunction, Experimental PCOSAbstract
Background: Polycystic ovary syndrome (PCOS) is a complex endocrine–metabolic disorder characterized by reproductive dysfunction, insulin resistance, chronic low-grade inflammation, oxidative stress, and altered energy homeostasis. Emerging evidence suggests that silent information regulator 1 (SIRT1), a nicotinamide adenine dinucleotide
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References
Azziz R, Carmina E, Chen Z, Dunaif A, Laven JSE, Legro RS, et al. Polycystic ovary syndrome. Nat Rev Dis Primers. 2016;2:16057.
Diamanti-Kandarakis E, Dunaif A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev. 2012;33(6):981-1030.
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