THE DEFICIENCY OF VITAMIN D IS COMMON IN TERTIARY CARE HOSPITAL SUFFICIENTS WITH NONALCOHOLIC FAT LIVER DISEASE, WHICH IS IMPACTED BY HOSPITAL ISSUES
DOI:
https://doi.org/10.48047/z6689b53Keywords:
Non-alcoholic fatty liver disease, vitamin D, 25-hydroxyvitamin D, metabolic syndrome, steatosisAbstract
Background: Among the causes of liver disease, non-alcoholic fatty liver disease (NAFLD) is a growing problem. Metabolic syndrome is characterized by fat accumulation in the liver. As an insulin-sensitizing, anti-inflammatory, and antifibrotic compound, vitamin D contributes to NAFLD progression. It is unclear which events caused which events and which events were associated with each other. Methods: In this study, 250 adults with NAFLD who were diagnosed by ultrasound with a Hamaguchi score of 1 were included as subjects. The purpose of this study was to determine serum levels of 25-hydroxyvitamin D [25(OH) D]. Levels of deficiency range from 20 ng/mL to 29 ng/mL, while levels of inadequacy range from 20 to 29 ng/mL. There was an assessment of both the NAFLD Fibrosis Score and the FibroScan. Results: Among the patients, 52.0% were deficient in vitamin D, 28.0% insufficient, and 20.0% sufficient. A higher percentage of those with advanced NAFLD exhibited deficiencies (71.4% compared with 38.2% in Grade 1). Inverse correlation was found between serum 25(OH) D levels and CAP score (r=−0.36) and ALT (r=−0.31). A BMI of 27.5 (an OR of 2.4), metabolic syndrome (an OR of 2.1), and sedentary lifestyle (an OR of 1.8) independently predicted deficiency. Conclusions: Studies have shown that vitamin D deficiency contributes to worsening of hepatic steatosis in patients with NAFLD. Causation should be evaluated in the future, but routine 25(OH) D level screening and lifestyle-optimized vitamin D supplementation may be incorporated into NAFLD management protocols
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