Prognostic Determinants in Acute Paracetamol Toxicity: Integrating Clinical Features and Biomarkers for Outcome Prediction
DOI:
https://doi.org/10.48047/dk92t507Keywords:
Paracetamol; acetaminophen; overdose; acute liver injury; acute liver failure; prognosis; risk stratification; biomarkers; INR; hypoglycemia; renal injury; N-acetylcysteine; clinical toxicology.Abstract
Background: Acute paracetamol (acetaminophen) toxicity remains a leading cause of drug-induced acute liver failure worldwide. Although early administration of the antidote, N-acetylcysteine (NAC), markedly improves prognosis, the outcome prediction is still challenging in several practical scenarios: uncertain time of ingestion, delayed presentation, staggered or repeated supratherapeutic dosing, co-ingestions, and patients with evolving multiorgan dysfunction. Traditional risk assessment commonly relies on exposure h
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References
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