Hemophilic Arthropathy in Children: Impact of Inhibitors on Musculoskeletal Outcomes and Disease Progression

Authors

  • Mervat ATfy Mohammed , Hossam Mostafa Kamal , Mohamed Atia Mortada , Moursy Mabrouk Abdallah Attia Moursy Author

DOI:

https://doi.org/10.48047/d8w23156

Keywords:

Hemophilia; Pediatric hemophilia; Hemophilic arthropathy; Musculoskeletal assessment; Hemarthrosis; Hemophilia Joint Health Score (HJHS); Ultrasound; Magnetic resonance imaging; Joint evaluation; Early detection

Abstract

Background: Hemophilia is a hereditary X-linked bleeding disorder characterized by deficiency of coagulation factors VIII or IX, leading to recurrent bleeding episodes, particularly within joints and muscles. In pediatric patients, repeated hemarthroses represent the most significant  clinical manifestation, initiating a cascade of pathological events that culminate in hemophilic arthropathy

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References

Mannucci PM, Tuddenham EGD. The hemophilias—from royal genes to gene therapy. N Engl J Med. 2001;344(23):17731779.

Bolton-Maggs PHB, Pasi KJ. Haemophilias A and B. Lancet. 2003;361(9371):1801-1809.

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Published

2024-11-20

Issue

Vol. 53 No. 03 (2024): Year 2024, Volume 53, Issue 3

Section

Original

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How to Cite

Hemophilic Arthropathy in Children: Impact of Inhibitors on Musculoskeletal Outcomes and Disease Progression (Mervat ATfy Mohammed , Hossam Mostafa Kamal , Mohamed Atia Mortada , Moursy Mabrouk Abdallah Attia Moursy , Trans.). (2024). Cuestiones De Fisioterapia, 53(03), 7469-7482. https://doi.org/10.48047/d8w23156