Toxicity Profiling and In Silico Evaluation of Embelia ribes Phytochemicals as Human Lysyl Oxidase-Like 2 (hLOXL2) Inhibitors

Authors

  • Indugayathrie VT, Dr. Radha krishnan Author

DOI:

https://doi.org/10.48047/v6th3357

Keywords:

.

Abstract

Human lysyl oxidase-like 2 (hLOXL2) is a copper-dependent enzyme that catalyzes oxidative deamination of lysine residues inextracellular matrix (ECM) proteins. Dysregulated LOXL2 activity is linked with pathological fibrosis, tumor progression and metastasis, and abnormal tissue remodeling. 

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References

Saravanan L, Mahale A, Gota V, Khandelia P, Kulkarni OP. Necrostatin-1 attenuates oral squamous cell carcinoma by modulating tumour immune response in mice. Fundam Clin Pharmacol. 2025 Jun;39(3):e70008.

Noor L, Hafeez A, Rahman MA, Vishwakarma KK, Kapoor A, Ara N, et al. Demystifying the Potential of Embelin-Loaded Nanoformulations: a Comprehensive Review. AAPS PharmSciTech. 2024 Oct 21;25(8):249.

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Published

2024-11-20

Issue

Vol. 53 No. 03 (2024): Year 2024, Volume 53, Issue 3

Section

Original

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How to Cite

Toxicity Profiling and In Silico Evaluation of Embelia ribes Phytochemicals as Human Lysyl Oxidase-Like 2 (hLOXL2) Inhibitors (Indugayathrie VT, Dr. Radha krishnan , Trans.). (2024). Cuestiones De Fisioterapia, 53(03), 7269-7277. https://doi.org/10.48047/v6th3357