Influence of Early Postmortem Interval on the Detection of Hepatic Diazepam Concentrations in Male Albino Rats
DOI:
https://doi.org/10.48047/18wajd25Keywords:
postmortem interval, forensic toxicology, diazepam, GC-MS.Abstract
Background: Background: The increasing misuse of benzodiazepines (BZDs) in drug-facilitated crimes (DFCs) has become a serious concern for forensic experts, healthcare professionals, and legal authorities. These drugs, which are commonly prescribed for anxiety and sleep disorders, are also used to commit crimes such as sexual assault and robbery. Their sedative and memory-blocking effects render them particularly dangerous. So, the aim of the present work is to study the effect of postmortem interval on diazepam concentration inliver tissue after acute oral lethal dose administration in male albino rats, using Gas Chromatography- Mass Spectrometry (GC-MS)
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References
Poloz, Yekaterina O., and Danton H. O’Day. "Determining time of death: temperature-dependent postmortem changes in calcineurin A, MARCKS,CaMKII, and protein phosphatase 2A in mouse." International Journal of Legal Medicine 123, no. 4 (2009): 305-314.
Sharma, R., Bhute, A. R., & Bastia, B. K. (2022). Application of artificial intelligence and machine learning technology for the prediction ofpostmortem interval: A systematic review of preclinical and clinical studies. Forensic science international, 340, 111473.
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