Cytokine Signaling Dysregulation and Pruritus in Cutaneous T-Cell Lymphoma: Emerging Molecular Insights and Clinical Correlations
DOI:
https://doi.org/10.48047/183dw954Keywords:
Cytokine Signaling, Pruritus, Cutaneous T-Cell LymphomaAbstract
Background: Cutaneous T-cell lymphoma (CTCL), particularly Mycosis Fungoides, represents a heterogeneous group of non-Hodgkin lymphomas characterized by malignant proliferation of skin-homing T lymphocytes and a chronic, often indolent clinical course. Among its most debilitating and frequently reported symptoms is pruritus, which significantly impairs quality of life and often correlates withdisease progression. Despite its clinical importance, the molecular mechanisms underlying pruritus
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References
Willemze R, Cerroni L, Kempf W, et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood. 2019;133(16):1703-1714.
Ibrahim MA, Eltayeb N, Ibrahim MM, et al. Suggested guidelines for the treatment of mycosis fungoides in countries with limited resources. Dermatol Res Pract. 2023;2023:1360740.
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