Revisiting the Hypothalamic–Pituitary–Gonadal Axis in β-Thalassemia: Is Kisspeptin the Next-Generation Diagnostic Tool?

Authors

  • Laila M Sherief1, Mervat Atfy , Ihab Abdelhameed, Doaa Metwaly , Esraa Hassan Ibrahim Elsayed Author

DOI:

https://doi.org/10.48047/gy5v3j58

Keywords:

b-thalassemia major; delayed puberty; hypogonadotropic hypogonadism; kisspeptin; gonadotropin-releasing hormone; HPG axis; iron overload; pediatric endocrinology; dynamic testing; neuroendocrine dysfunction

Abstract

Background: Delayed puberty is one of the most prevalent endocrine complications in adolescents with β-thalassemia major, primarily resulting from iron overload–induced dysfunction of the hypothalamic–pituitary–gonadal (HPG) axis. Despite advances in transfusion  protocols and iron chelation therapy, hypogonadotropic

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References

De Sanctis V, Soliman AT, Elsedfy H, et al. Endocrine complications in thalassemia major: an update. J Clin Res Pediatr Endocrinol. 2016;8(4):361-372.

Palmert MR, Dunkel L. Clinical practice. Delayed puberty. N Engl J Med. 2012;366(5):443-453.

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Published

2024-11-20

Issue

Vol. 53 No. 03 (2024): Year 2024, Volume 53, Issue 3

Section

Original

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How to Cite

Revisiting the Hypothalamic–Pituitary–Gonadal Axis in β-Thalassemia: Is Kisspeptin the Next-Generation Diagnostic Tool? (Laila M Sherief1, Mervat Atfy , Ihab Abdelhameed, Doaa Metwaly , Esraa Hassan Ibrahim Elsayed , Trans.). (2024). Cuestiones De Fisioterapia, 53(03), 7124-7133. https://doi.org/10.48047/gy5v3j58