Hippocampal Architecture and Neuroplasticity: Anatomical Foundations of Memory Circuits and Their Susceptibility to Dietary Modulators
DOI:
https://doi.org/10.48047/1662kg64Keywords:
Hippocampal formation; Dentate gyrus; Cornu ammonis (CA1–CA4); Subiculum; Entorhinal cortex; Perforant path; Fornix; Limbic circuitry; Cytoarchitecture; Neuroplasticity; Pattern separation; Memory consolidation; Vascular supply; Metabolic vulnerability; Dietary modulators; Artificial sweeteners; Oxidative stress; Activity-dependent gene expression.Abstract
Background: The hippocampal formation is a highly specialized medial temporal lobe structure that supports episodic memory, spatial navigation, and context-dependent learning through a tightly organized laminar architecture and stereotyped intrinsic circuitry. Its neuroanatomy is defined by distinct subfields—dentate gyrus, cornu ammonis (CA1–CA4), and the subicular complex—eachcharacterized by unique cytoarchitecture, microcircuit motifs
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References
Waxman SG. The limbic system. In: Waxman SG, ed. Clinical Neuroanatomy. 27th ed. New York: McGraw-Hill; 2013.
LeDoux J, Damasio A. Emotions and feelings. In: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, eds. Principles of Neural Science. 5th ed. New York: McGraw-Hill; 2012:1079-1094.
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