THE EFFICACY AND SAFETY OF LEBRIKIZUMAB PLUS TOPICAL CORTICOSTEDOIDS IN MODERATETO SEVERE ATOPIC DERMATITIS.
DOI:
https://doi.org/10.48047/vwmbcr61Keywords:
Atopic dermatitis, lebrikizumab, topical corticosteroids, phase 3 trial, EASI-75Abstract
Inflammatory and chronic skin conditions such as AD have a serious impact on patients' quality of life. A phase 3 randomised, placebo-controlled trial, ADhere (NCT04250337) examined the efficacy and safety of low-to-mid potency topical corticosteroids (TCSs) that contain IL-13 monoclonal antibody in moderate and severe AD, adolescents, and adults. Combining lebrikizumab and TCS was found to have tremendous effects on skin clearance and itch intensity, sleep disturbances, and quality of life in the trial. There has already been a statistically significant increase in EASI-75 week 4 and IGA (0,1) week 8 responses. Combination therapy was highly compliant and mild or moderate adverse events were reported mainly. In addition, these findings support the use of lebrikizumab and TCS as an effective method of managing moderate and severe AD.
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