Can Targeting Oxidative Stress and Inflammation with Lycopene Prevent Paclitaxel-Induced Spermatogenic Disruption?
DOI:
https://doi.org/10.48047/5e3j3b02Keywords:
Paclitaxel; Lycopene; Testicular toxicity; Oxidative stress; Inflammation; Spermatogenesis; Reactive oxygen species; Chemotherapy-induced gonadotoxicity; Antioxidants; NF-κB.Abstract
Background: Paclitaxel is a widely used chemotherapeutic agent effective against various solid malignancies, including breast, ovarian, and lung cancers. Despite its therapeutic efficacy, accumulating experimental and clinical evidence indicates that paclitaxel exerts deleterious effects on the male reproductive system. Testicular tissue, characterized by rapid germ cell proliferation and high polyunsaturated fatty acid content, is particularly vulnerable to chemotherapeutic-induced
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References
Ahmed Khalil A, et al. Recent developments and anticancer therapeutics of paclitaxel: An update. Curr Pharm Des. 2022;28(41):3363-3373.
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